The cat-like cry, which is the most common symptom, becomes less noticeable over time. Some symptoms are severe while others are so minor they may go undiagnosed. The severity of your child’s symptoms depends on how much genetic information is missing from chromosome 5. What are the symptoms of cri-du-chat syndrome? Your unborn child has a slightly increased risk of being born with the condition if you have a family history of cri-du-chat syndrome. This results in the loss of genetic material and can cause cri-du-chat syndrome. However, if you pass the defective chromosome to your child, it may become unbalanced. ![]() This is a defect in the chromosome that does not result in the loss of genetic material. It’s possible that you may carry a type of defect called a balanced translocation. About 90 percent are presumed to be random mutations. Only about 10 percent of cases come from a parent who has a deleted segment, according to the National Human Genome Research Institute. The syndrome is not typically inherited, though. This means the child develops the syndrome when fertilization occurs.Īccording to the Orphanet Journal of Rare Diseases, the chromosome deletion comes from the father’s sperm in about 80 percent of cases. In most cases, the chromosome break happens while the parent’s sperm or egg cell is still developing. The exact reason for the chromosome 5 deletion is unknown. These complications will depend on the severity of the syndrome.Ībout half of children with cri-du-chat syndrome learn enough words to communicate, and most grow up to be happy, friendly, and sociable. But the child will most likely have lifelong physical or developmental complications. Most fatal complications occur before the child’s first birthday.Ĭhildren with cri-du-chat who reach age 1 generally will have a normal life expectancy. A small percentage of infants with cri-du-chat syndrome are born with serious organ defects (especially heart or kidney defects) or other life-threatening complications that can result in death. The syndrome is more noticeable as the child ages, but becomes difficult to diagnose past age 2.Ĭri-du-chat also carries many disabilities and abnormalities. The larynx develops abnormally due to the chromosome deletion, which affects the sound of the child’s cry. Infants with the syndrome produce a high-pitched cry that sounds like a cat. ![]() “Cri-du-chat” means “cry of the cat” in French. But it’s one of the more common syndromes caused by chromosomal deletion. ![]() It’s a rare condition, occurring in only about 1 in 20,000 to 1 in 50,000 newborns, according to the Genetics Home Reference. Also called cat’s cry or 5P- (5P minus) syndrome, it’s a deletion on the short arm of chromosome 5. Cri-du-chat syndrome is a genetic condition.
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